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Home > Newsletters > March 2007 > Recent Research

Points - Recent Research

The Effectiveness of Acupuncture for Osteoarthritis of the Knee

Identification of Human Dopamine Receptors Agonists from Chinese Herbs

Protective Effect of Gui Qi Mixture on the Progression of Diabetic Nephropathy in Rats

The Effectiveness of Acupuncture for Osteoarthritis of the Knee

White A, Foster N, Cummings M, Barlas P.

OBJECTIVE: To determine the effectiveness of acupuncture treatment for
pain and function of patients with osteoarthritis of the knee.
METHODS: A systematic review of randomised controlled trials was
performed, including a meta-analysis which combined the results of
trials that used adequate acupuncture treatment and used WOMAC scores
to measure the effect. The internal validity (quality) and
heterogeneity of studies were taken into account. RESULTS: Thirteen
studies were available, of which eight, involving 2362 patients, could
be combined. For both reduction of pain and improvement of function,
acupuncture was significantly superior to sham acupuncture (P<0.05 for
all comparisons) in both the short term and the long term. Compared
with no additional intervention (usual care), acupuncture was again
significantly superior for pain and function. The treatment effects
were maintained after taking account of quality and heterogeneity in
sensitivity analyses. CONCLUSION: Acupuncture is an effective
treatment for osteoarthritis of the knee. Its overall effect size is
0.8, and it can be considered instead of non-steroidal
anti-inflammatory drugs for patients whose symptoms are not controlled
by education, exercise, weight loss if appropriate and simple
analgesics. Further research is necessary into the most efficient way
of delivering acupuncture, and its longer term benefits.

Acupunct Med. 2006 Dec;24(Suppl):S40-48.

Source PubMed


Identification of Human Dopamine Receptors Agonists from Chinese Herbs

Zhang YL, et al. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China.

AIM: To find human dopamine receptors, especially D1-like receptor
specific agonists from Chinese herbs as potential antihypertension
drug leads. METHODS: Two D1-like receptor cell lines carrying a
beta-lactamase reporter gene, and a D2 receptor cell line coexpressing
a promiscuous G protein G15 were constructed using HEK293 cells. A
natural compound library made from fractionated samples of herbal
extracts was used for high-throughput screening (HTS) against one of
the cell lines, HEK/D5R/CRE-blax. The interested hits were evaluated
for their activities against various dopamine receptors. RESULTS:
Fourteen hits were identified from primary screening, of which 2 of
the better hit samples, HD0522 and HD0059, were selected for further
material and activity analysis, and to obtain 2 compounds that
appeared as 2 single peaks in HPLC, HD0522H01 and HD0059H01. HD0059H01 could activate D1, D2, and D5 receptors, with EC(50 ) values of 2.28 microg/mL, 0.85 microg/mL, and 1.41 microg/mL, respectively. HD0522H01 could only activate D1R and D5R with EC(50 ) values of 2.95 microg/mL and 8.38 microg/mL. CONCLUSION: We established cellbased assays for 3 different human dopamine receptors and identified specific agonists HD0522H01 and HD0059H01 through HTS. The specific agonist to D1-like receptors, HD0522H01, may become a new natural product-based drug lead for antihypertension treatment.

Acta Pharmacol Sin. 2007 Jan;28(1):132-9.

Source: PubMed


Protective Effect of Gui Qi Mixture on the Progression of Diabetic Nephropathy in Rats

Zhang YW, et al. Department of Chinese with Western Medicine, Zhongnan Hospital, Wuhan University, Wuhan, China.

Huang Qi (root of Astragalus membranaceus) and Dang Gui ( Angelica
sinensis), two of the most widely used herbs in traditional Chinese
medicine, have been proven to be effective in the treatment of
diabetes mellitus (DM) although the underlying molecular mechanisms
are not fully elucidated. This study was designed to investigate the
protective effect of Dang Gui and Huang Qi mixture (GQM) on the
development of diabetic nephropathy in rats with streptozotocin
(STZ)-induced DM and the possible underlying molecular mechanism. The
diabetic animal model was made by a single intraperitoneal injection
of STZ and then treated with GQM or benazepril. Blood glucose,
triglyceride (TG), cholesterol (CHO), high density lipoprotein (HDL),
serum creatinine (Scr), creatinine clearance rate (Ccr), blood urea
nitrogen (BUN), urine beta (2)-microglobin (beta (2)-MG), kidney/body
weight (K/B) ratio, glomerular area (GA), renal transforming growth
factor-beta (1) (TGF-beta (1)) mRNA expression and blood and renal
angiotensin II (AngII) expression were determined 8 weeks after the
treatment. The blood glucose, CHO and TG levels, BUN, SCr, Ccr. K/B
ratio, GA, the excretion of beta (2)-MG, renal TGF-beta (1) mRNA
expression and blood and renal AngII expression were significantly
increased while the HDL level was decreased 8 week after STZ
injection. The changes in blood glucose, TG, CHO and HDL were reversed
by GQM, not by benazepril, whereas the changes in other variables were
reversed by both GQM and benazepril. Our results suggest that GQM
alleviates the disorder in blood glucose and lipids, protects against
the progression of renal nephropathy in diabetic rats, probably by
inhibiting the expression of AngII and TGF-beta (1) mRNA.

Exp Clin Endocrinol Diabetes. 2006 Nov;114(10):563-8

Source: PubMed


This Month's Articles

March 2007
Volume 5, Number 3

Pain Management

Holistic Veterinarians

Acupuncture Treatment for Substance Abuse

Recent Research

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