Points - Recent Research
Acupuncture Efficacy in the Treatment of Persistent Primary Nocturnal Enuresis
Immunomodulatory Activities of Polysaccharides Isolated from Taxillus Chinensis and Uncaria Rhyncophylla (Sang Ji Sheng and Gou Teng)
Neuroprotective Effects of Huang-Lian-Jie-Du-Decoction on Ischemic Stroke Rats Revealed by 1H NMR Metabolomics Approach

Acupuncture Efficacy in the Treatment of Persistent Primary Nocturnal Enuresis

El Koumi MA, et al. Departments of Pediatrics, Faculty of Medicine, Zagazig University, Egypt.

This study aimed to assess the therapeutic efficacy of traditional Chinese acupuncture in the treatment of persistent primary nocturnal enuresis (PNE). Methods: Fifty children and adolescents suffering from persistent PNE were recruited from the Pediatrics and Urology Outpatient Clinic of Zagazig University Hospital during the year 2010. They included 31 boys and 19 girls, with a mean age of 116 years (range 9-17 years). The children and their parents underwent thorough counseling followed by two courses of treatment, each course administered over 10 consecutive days. Patients were instructed to continue regular follow-up, every three months, after starting the therapy. The response rate (cure, improvement, or failure) was monitored by recording dry nights and the number of spontaneous arousals to void per week on a calendar. Children who showed partial or no response after six months of observation received another two courses of acupuncture therapy, and were followed up for a further six months period. Results: After the initial two courses of treatment, the cure rate at six months was 76% with an additional 18% achieving partial improvement. Twelve children needed another two courses of treatment. After one year of follow-up, 92% of patients showed complete cure and 8% showed failure of acupuncture therapy. Conclusion: Acupuncture treatment in patients with PNE appears effective in increasing the percentage of dry nights, with stable results even after the end of treatment courses. Further controlled studies are needed to confirm these results and to elucidate the therapeutic mechanism of acupuncture.

Arab J Nephrol Transplant.2013 Sep;6(3):173-6.

Source: PubMed

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Immunomodulatory Activities of Polysaccharides Isolated from Taxillus Chinensis and Uncaria Rhyncophylla (Sang Ji Sheng and Gou Teng)

Zhang L, et al. School of Science and Health, University of Western Sydney, Locked Bag 1797, Penrith South DC, NSW 1797, Australia.

Taxillus chinensis and Uncaria rhyncophylla are the herbs used in traditional Chinese anticancer formulations. During the past decade, research on plant polysaccharides has gained importance due to their therapeutic value and minimum side effects. In this study, hot water extraction method was employed to isolate polysaccharides from the stems of T. chinensis and stems with hooks of U. rhyncophylla. Size-exclusion chromatography was then used for further fractionation. Separated fractions from T. chinensis were designated as TCP-1, TCP-2 and TCP-3 and those from U. rhyncophylla were termed UC-1 and UC-2. Their sugar compositions were estimated using gas chromatography that revealed the presence fructose, glucose, xylose, arbinose, and rhamnose. Amino acid analysis of these fractions has indicated that they are protein-bound polysaccharides. The antioxidant activities were investigated using DPPH and yeast assays. The ability of these polysaccharide fractions to stimulate mouse macrophages was measured using Griess reagent and ELISA test. The results revealed that some of the isolated fractions (TCP-2, TCP-3, UC-1 and UC-2) displayed significant antioxidant activities and were also found to be effective immunomodulators in a concentration-dependent manner. Outcomes of this research strongly indicate that U. rhyncophylla and T. chinensis have therapeutic potential to be used for the treatment of cancer.

Carbohydr Polym. 2013 Nov 6;98(2):1458-65. doi: 10.1016/j.carbpol.2013.07.060. Epub 2013 Aug 6.

Source: PubMed

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Neuroprotective Effects of Huang-Lian-Jie-Du-Decoction on Ischemic Stroke Rats Revealed by 1H NMR Metabolomics Approach

Wang PR, et al. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.

Huang-Lian-Jie-Du-Decoction (HLJDD) is a representative antipyretic and detoxifying recipe in traditional Chinese medicine (TCM). This formula and its component herbs like Radix Scutellariae, Fructus Gardeniae show a variety of neuroprotective activities and have been used for the treatment of nervous system diseases including stroke. To comprehensively and holistically assess its therapeutic effect on ischemic stroke, a novel integrative metabolomics approach was applied. A rat ischemic stroke model was established by introduction of transient middle cerebral artery occlusion (MCAO) followed by reperfusion. The neurological deficit, cerebral infarct size and morphological abnormality were evaluated. An NMR technique combined with appropriate statistical analyses was then performed to explore the metabonomic profiles of serum and brain tissue extracts. Pattern analysis of the 1H NMR data disclosed that HLJDD could relieve stroke rats suffering from the ischemia/reperfusion (I/R) injury by ameliorating the disturbance in energy metabolism, membrane and mitochondrial metabolism, neurotransmitter and amino acid metabolism, alleviating the oxidative stress from reactive oxygen species (ROS) and the inflammatory damage, and recovering the destructed osmoregulation.

J Pharm Biomed Anal. 2013 Aug 29;88C:106-116. doi: 10.1016/j.jpba.2013.08.025.

Source: PubMed

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