Points - Recent Research
Electroacupuncture Enhances Cell Proliferation and Neuronal Differentiation in Young Rat Brains
The Mechanisms of Action of Tianhua on Antitumor Activity in Lung Cancer Cells
Acupuncture Therapy for Apoplectic Aphasia

Electroacupuncture Enhances Cell Proliferation and Neuronal Differentiation in Young Rat Brains

Gao J, et al. Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, Zhengzhou, 450052, China.

To investigate the effect of electroacupuncture on cell proliferation and differentiation in young rat hippocampus, postnatal day-14 rats were assigned randomly to control, ketamine anesthesia, nonacupoint, or acupoint electroacupuncture groups. Electroacupuncture was applied at bilateral acupoints (Quchi, Waiguan, Huantiao, and Zusanli) 30 min daily for 7 successive days. The proliferation and neuronal differentiation of proliferated surviving cells in the dentate gyrus were evaluated at 4 weeks after last stimulation. The stimulatory effect of electroacupuncture on cell proliferation had a long-lasting effect, as indicated by the increased phosphor-histone H3-positive cells. The number of proliferated and survival cells, indicated by BrdU labeling, was highest in the electroacupuncture group. The number of newly differentiated neurons, as indicated by BrdU/NeuN double labeling, was significantly higher in the electroacupuncture group than in any of the other groups. This finding provides a theoretical basis for the clinical application of acupuncture to cerebral injury rehabilitation in children.

Neurol Sci. 2010 Sep 18.

Source: PubMed


The Mechanisms of Action of Tianhua on Antitumor Activity in Lung Cancer Cells

Li, CT, et al. Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichung, Taiwan.

Tianhua (TH-R) is extracted from Trichosanthes kirilowii Maxim (Cucurbitaceae) containing trichosanthin, a traditional Chinese medicine, which has been locally reported to have good anticancer effects in vivo in both animal and human models. However, there have been several reports that trichosanthin has an anticancer effect involving apoptosis. Objective: To investigate other anticancer effects of TH-R, various tumorigenesis parameters were verified. Materials and methods: Telomerase activity, anti-apoptosis, anti-migration and immunomodulatory activity were estimated by telomeric repeat amplification protocol assay (TRAP), flow cytometry, Boyden chamber assay and ELISA assay, respectively. Results: In our studies, we are the first to find that TH-R had a cytotoxic effect on lung cancer cells in MTS assays; it could change the cell cycle distribution of human lung cancer cells (A549 cell line) and induce apoptosis. Further anti-telomerase effects in human lung adenocarcinoma A549 cells using the TRAP assay were noted. TH-R also had an aggregation effect on peripheral blood lymphocytes, but no effect on stimulating peripheral lymphocytes to produce human interferon-gamma(IFN-gamma). TH-R could inhibit the migration, or metastatic ability, of A549 cells by Boyden chamber assay. In the oral feeding therapy of an in vivo mouse model, there was an initial inhibition of A549 cancer cell growth, but no statistical difference after one month of therapy. Discussion and conclusion: It has been proven that medicinal herbs such as Tianhua have positive effects against cancer through preventing or inhibiting the process of lung tumorigenesis.

Pharm Biol.2010 Aug 25.

Source: PubMed


Acupuncture Therapy for Apoplectic Aphasia: A Systematic Review

Pang Y, et al. Department of Acupuncture, The First Affiliated Hospital of Guanngxi TCM University, Nanning 530023, China. py343@sohu.com

OBJECTIVE: To assess the therapeutic effect of acupuncture for apoplectic aphasia. METHODS: A systematic review of the relevant randomized controlled trials (RCTs) of acupuncture for apoplectic aphasia was performed with Cochrance system assessment methods. The quality of researches was reviewed one by one, and data was extracted by two reviewers independently. Meta-analysis was conducted with the assistance of RevMan 5.0 software. RESULTS: Eleven randomized controlled trials (RCTs) involving 756 patients were included. Meta-analysis indicated that there was statistical difference between acupuncture and language training groups on cured rate with [RR = 1.74, 95% CI (1.10, 2.74), P = 0.02] at the end of treatment. However, acupuncture combined language training group was statistically superior to language training group on cured rate with [RR = 3.01, 95% CI (1.81, 5.01), P < 0.000 1], language function score with [WMD =10.54, 95% CI (7.86, 13.21), P < 0.000 01], oral expression with [WMD = 8.86, 95% CI (7.38, 10.35), P < 0.000 01]. CONCLUSION: It is approved that acupuncture (or acupuncture combined language training) is effective for apoplectic aphasia. But the quality of inclusive literature is low. Therefore, more RCTs of high methodological quality is requested to be carried out.

Zhongguo Zhen Jiu. 2010 Jul;30(7):612-6.

Source: PubMed


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