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Home > Newsletters > October 2006 > Recent Research

Points - Recent Research

Acupuncture Stimulation of ST-36 (Zusanli) Significantly Mitigates Acute Lung Injury in Lipopolysaccharide-Stimulated Rats

Acupuncture for Initiation of Labor in Nulliparous Women

Effects on Herba Epimedii and Radix Astragali on Tumor Necrosis Factor-Alpha and Nuclear Factor-Kappa B in Asthmatic Rats


Acupuncture Stimulation of ST-36 (Zusanli) Significantly Mitigates Acute Lung Injury in Lipopolysaccharide-StimulatedRats

Huang CL , et al. Acupuncture and Moxibustion Institute, Nanjing University of Traditional Chinese Medicine, Nanjing, China.

BACKGROUND: We sought to investigate the potential therapeutic effects of acupuncture stimulation of ST-36 (Zusanli) on endotoxemia-induced acute lung injury in lipopolysaccharide (LPS)-stimulated rats. METHODS: Sixty rats were randomized into six groups (n = 10): (i) lipopolysaccharide (LPS) control group, (ii) normal saline (N/S) control group, (iii) LPS plus ST-36 group, (iv) N/S plus ST-36 group, (v) LPS plus sham point (Sham) group, and (vi) N/S plus Sham group. Manual acupuncture stimulation of ST-36 (designated as 'ST-36') or a 'non-acupoint' (designated as 'Sham') was performed in lightly immobilized rats for 30 min. Then, LPS injection was employed to induce sepsis. Rats were killed at 6 h after LPS injection and lung injury, nitric oxide (NO) biosynthesis and inducible NO synthase (iNOS) expression were assayed. RESULTS: Significant lung injury, pulmonary iNOS expression and systemic and pulmonary NO biosynthesis were noted in the LPS groups. Rats in the LPS plus Sham group had lung injury, pulmonary iNOS expression, systemic and pulmonary NO biosynthesis similar to those observed in the LPS group. However, the degree of lung injury, pulmonary iNOS expression and pulmonary NO biosynthesis, but not systemic NO biosynthesis, were significantly attenuated in the LPS plus ST-36 group as compared with those in both the LPS group and the LPS plus Sham group. CONCLUSION: Acupuncture stimulation of ST-36 may be effective as a prophylaxis measure against sepsis. However, results from this study do not support the use of acupuncture for the treatment of sepsis.

Acta Anaesthesiol Scand. 2006 Jul;50(6):722-30.

Source PubMed

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Acupuncture for Initiation of Labor in Nulliparous Women

Harper TC , et al. Department of Obstetrics and Gynecology, University of North Carolina, NC, USA.

Objective. To evaluate the utility of outpatient acupuncture for labor stimulation.Methods. Nulliparous women at 39 4/7 weeks or greater with a singleton gestation and Bishop score of less than 7 were randomized to usual medical care (control group) versus usual care and three outpatient acupuncture treatments (acupuncture group). Each treatment consisted of eight needles applied to bilateral points LI4, SP6, UB31, and UB32. The primary outcome was time elapsed from the time of randomization to delivery. Secondary outcomes included rates of cesarean section and induction of labor. Medical records were abstracted for maternal demographic, medical, and delivery outcome data. A priori sample size calculation revealed that 56 women were required to detect a 72-hour difference in delivery time with a power of 83% and an alpha of 0.05. Student's t-test, Chi-square, and Kaplan-Meier statistics were used to compare groups.Results. Fifty-six women were randomized and completed the study procedures. Race, age, gestational age, and cervical Bishop score were similar in both groups. Mean time to delivery occurred 21 hours sooner in the acupuncture group, but this difference did not reach statistical significance (p = 0.36). Compared to controls, women in the acupuncture group tended to be more likely to labor spontaneously (70% vs. 50%, p = 0.12) and less likely to deliver by cesarean section (39% vs. 17%, p = 0.07). Of women who were not induced, those in the acupuncture group were more likely to be delivered than the controls at any point after enrollment (p = 0.05).Conclusion. Acupuncture is well tolerated among term nulliparous women and holds promise in reducing interventions that occur in post-term pregnancies.

J Matern Fetal Neonatal Med. 2006 Aug;19(8):465-70.

Source: PubMed

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Effects on Herba Epimedii and Radix Astragali on Tumor Necrosis Factor-Alpha and Nuclear Factor-Kappa B in Asthmatic Rats

Xie JY , et al. Institute of Integrative Medicine, Huashan Hospital of Fudan University, Shanghai 200040.

OBJECTIVE: To observe the effects of Herba Epimedii and Radix Astragali, the two Chinese herbs for replenishing Shen and strengthening qi, on tumor necrosis factor-alpha (TNF-alpha, one of the pro-inflammatory factors) and nuclear factor-kappa B (NF-kappa B) in asthmatic rats. METHODS: Rats were randomly divided into five groups: the normal saline control group, the asthma model group and the three treated groups treated with high, medium and low dose of the Chinese herbs. Serum TNF-alpha and NF-kappa B activity in pulmonary tissue were detected with enzyme-linked immunosorbent assay and immunohistochemistry respectively. RESULTS: Herba Epimedii and Radix Astragali could effectively reduce the production of TNF-alpha and inhibit NF-kappa B activity, and the efficacies in the three treated group were similar, showing insignificant difference among them. CONCLUSION: Application of Herba Epimedii and Radix Astragali in the attack or remission stage of asthma could restrain the development of inflammation by reducing the production of TNF-alpha and inhibiting NF-kappa B activity.

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Aug;26(8):723-7

Source: PubMed

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This Month's Articles

October 2006
Volume 4, Number 10

Enjoy the Energy of Fall

Acupuncture: Rediscovering an Ancient Art

Chinese Face Reading for the Single Girl

Recent Research

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