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Home > Newsletters > March 2008 > Recent Research

Points - Recent Research

Dan Zhi Xiao Yao Wan and its Constituent Herbs on Antioxidant Activity and Inhibition of Nitric Oxide Production

Randomized and Controlled Clinical Study of Modified Prescriptions of Simiao Pill In the Treatment of Acute Gouty Arthritis

Acupuncture at Xuanzhong (GB 39) and Ashi Points for Treatment of Orthopedic Postoperative Pain

Dan Zhi Xiao Yao Wan and its Constituent Herbs on Antioxidant Activity and Inhibition of Nitric Oxide Production

Liao H, et al. Centre for Phytochemistry and Pharmacology, Southern Cross University, Lismore NSW 2480, Australia and Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China

Dan Zhi Xiao Yao Wan (DW) is a common 10 herbs formulation in China for regulating several clinical conditions affecting women. This research tried to explain one of DW's functions, purging heat, using in vitro pharmacological analyses. The whole formulation and each single herb of DW were compared based on antioxidant activity with the oxygen radical absorbance capacity (ORAC) assay, and for their inhibitory effect (IE) on nitric oxide (NO) production by lipopolysaccharide (LPS)-activated RAW 264.7 macrophages with the Griess assay. The results showed that DW as a whole formulation had both antioxidant activity and an IE on NO production, while the individual herb component of DW varied in their ORAC values and inhibition of NO production. The ORAC value of the whole DW was 450 mumol TE g(-1). The order of antioxidant (ORAC) activity of the single herbs was: Mentha haplocalyx (1352 mumol TE g(-1)) > Glycyrrhiza uralensis (1184 mumol TE g(-1)) > Gardenia jasminoides (1129 mumol TE g(-1)) > Paeonia suffruticosa (465 mumol TE g(-1)), with the contributions being additive rather than synergistic. The production of nitrite by stimulated RAW 264.7 murine macrophages (unstimulated: 0.5 +/- 0.1 muM versus LPS: 38.9 +/- 2.3 muM) was significantly inhibited (P < 0.05) by M. haplocalyx, G. jasminoides, Bupleurum chinense and Paeonia lactiflora. DW as a whole had an IE on NO production, but this was not significant. The single herb M. haplocalyx had the highest ORAC value and the highest IE on NO production, followed by G. jasminoides. Both of these herbs have the 'purging heat' property in the theory of traditional Chinese medicine and this property of the samples may be correlated with the antioxidant activity and IE on NO production.

Evid Based Complement Alternat Med. 2007 Dec;4(4):425-30.

Source PubMed


Randomized and Controlled Clinical Study of Modified Prescriptions of Simiao Pill In the Treatment of Acute Gouty Arthritis

Shi XD, et al. China Academy of Chinese Medical Sciences, Beijing, (100700), China,

Objective: To investigate the compatibility of a modified prescription of Simiao Pill () in the treatment of acute gouty arthritis and to verify the clinical efficacy and safety of the drug through a clinical trial. Methods: A randomized and controlled clinical trial was designed based on clinical epidemiological principles. A total of 07 patients with acute gouty arthritis were enrolled and randomly assigned to four groups. The first group (Group I) included 7 patients taking gout prescription II; the second group (Group II) included 27 patients taking gout prescription II; the third group (Group III) included 28 patients taking gout prescription III; and the fourth group (control group) included patients taking indomethacin and Benzobromarone as a control group. The duration of the treatment in all groups was two weeks. After the treatment, the index of blood uric acid, blood leukocyte count, score of clinical symptoms, etc. were observed and measured. Results: The total clinical effective rate of the three different modified prescriptions of the Simiao Pill was above 96%, significantly superior to that of the control group (68%, P<0.05). In terms of the improvement of main symptoms, the scores of four symptoms in all TCM treatment and control groups decreased after treatment, with statistically significant differences (P<0.0 ). Moreover, the scores markedly fell more so in the three Chinese herb groups than in the control group, and especially in Group III (P<0.05). There was a statistically significant difference in blood uric acid values before and after the treatment in the same group but no significant inter-group difference was seen. Conclusion: The modified prescriptions, based on the clinical research, clinical experience and traditional Chinese medicine theory, did show a better effect than Western medicine in this clinical study. Moreover, the prescriptions were precise, with the herbs inexpensive and readily available. The patients had good compliance with less adverse reactions noted. The modified prescription has a favorable prospect for future development and is worthy of further blind trials with larger samples.

Chin J Integr Med. 2008 Jan 25

Source: PubMed


Acupuncture at Xuanzhong (GB 39) and Ashi Points for Treatment of Orthopedic Postoperative Pain

Sun ZH, et al. Section of Acupuncture, The Third Affiliated Hospital of Luohe Medical Higher Training School, Henan 462002, China.

OBJECTIVE: To compare the therapeutic effects between acupuncture and Bezoxazocine injection in treatment of orthopedic postoperative pain. METHODS: Sixty patients were randomly divided into an acupuncture group and a medication group, 30 cases in each group. The patients in the acupuncture group were treated by acupuncture at Xuanzhong (GB 39) as main point and Ashi points for 30 minutes; the medication group were treated by intramuscular injection of Bezoxazocine injection, 20 mg once, three times per day. Then the pain changes within 48 hours were observed and recorded in two groups. RESULTS: The good rates at 24 hours and 48 hours were 89.2% and 100.0% in the acupuncture group and 81.4% and 96.3% in the medication group, respectively. The analgesic effect of acupuncture was better than that of Bezoxazocine injection (P < 0.05). CONCLUSION: Analgesic effect of acupuncture at Xuanzhong (GB 39) on orthopedic postoperative pain and Ashi points is better than Bezoxazocine injection.

Zhongguo Zhen Jiu. 2007 Dec;27(12):895-7

Source: PubMed


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