Electroacupuncture Reduces Neuroinflammatory Responses in Symptomatic
Amyotrophic Lateral Sclerosis Model
Yang EJ, et al. Department of Standard Research, Korea Institute of Oriental Medicine, 483 Expo-ro, Yuseong-gu, Daejeon, 305-811, Republic of Korea.
Amyotrophic lateral sclerosis (ALS) is a paralyzing disorder
that is characterized by the progressive degeneration and death of motor neurons. Acupuncture or
electroacupuncture (EA) has been used for the treatment of various conditions including osteoarthritis,
asthma, and other types of chronic pain conditions. It has been hypothesized that acupuncture exerts
anti-inflammatory and anti-nociceptive effects on inflammatory reactions processes. The purpose of this
study was to determine whether acupuncture at a specific acupoint could produce anti-inflammatory responses
and suppress motor neuron loss in the hG93ASOD1 mouse, commonly used as a model for inherited ALS. We
delivered EA at the Zusanli (ST36) acupuncture point in the symptomatic hSOD1G93A animal model. The
EA-treated mutant hSOD1 transgenic mice showed decreases in microglial cell activity and TNF-alpha
expression in the spinal cord and brain stem. Furthermore, EA significantly improved motor activity
compared to the control group and reduced neuronal cell loss in hSOD1G93A mice. Our research suggests a
potential functional link between EA therapy and anti-neuroinflammatory response in an ALS animal model.
J Neuroimmunol. 2010 May 9.
Effect of Penetrative Needling of Otopoints Combined
with Body Acupuncture on Limb Myodynamia and Neurofunction in Patients with Acute Cerebral Infarction
Li CF, et al. Section of Acu-moibustion of the 3rd
Hospital, Department of Acu-moxibustion, College of Chinese Medicine, China.
OBJECTIVE: To compare the therapeutic effects of different acupuncture methods in improving the myodynamia
and neuronfunction of patients with acute cerebral infarction (ACI). METHODS: A total of 90 ACI patients
were randomized into ear-acupuncture, scalp-acupuncture and body-acupuncture groups, with 30 cases in each.
For patients of ear-acupuncture group, the main otopoints used for penetrative needling were
Zhen(MA-AT)-Nie(MA-AT)-E(MA-AT) on the affected side in combination with Jian(MA-SF 4)-Suogu(MA-SF 5) and
Zhou(MA-SF 3)-Wan(MA-SF 2)-Zhi(MA-SF 1) for upper-limb paralysis, and with Tun (MA-AH 5)-Zuogushenjing(MA-AH
6), Kuan(MA-AH 4)-Xi(MA-AH 3), and Xi(MA-AH 3)-Huai(MA-AH 2)-Zhi(MA-AH 1) for lower-limb paralysis, and
body acupoints as Jianyu(LI 15), Hegu(LI 4), Huantiao(GB 30), Taixi(KI 3), etc. For patients of
scalp-acupuncture group, scalp-points used were Dingnie Qianxiexian(MS 6) and Dingnie Houxiexian(MS 7) on
the healthy side, and combined with body acupoints (the same as those mentioned above). For patients of
body-acupuncture group, only body acupoints were used. The treatment was given once daily for 14 days.
RESULTS: Comparison among 3 groups showed that the increased myodynamia of both upper and lower limbs in
ear-acupuncture and scalp-acupuncture groups was significantly superior to that of body-acupuncture group
(P < 0.01). The neurofunctional deficit scores of ear-acupuncture and scalp-acupuncture groups were
significantly lower than that of body-acupuncture group (P < 0.01) after the treatment. In comparison with
pre-acupuncture, the neurofunctional deficit scores of the 3 groups lessened considerably after the
treatment (P < 0.01). Of the 30 cases in each of ear acupuncture, scalp-acupuncture and body-acupuncture
groups, 0, 1 and 0 were cured basically, 21, 18 and 4 experienced marked improvement, 9, 11 and 20 were
improved, 0, 0 and 6 failed, respectively. The therapeutic effects of ear-acupuncture and scalp-acupuncture
were obviously superior to that of body-acupuncture group (P < 0.01). No significant differences were found
between ear-acupuncture and scalp-acupuncture groups in myodynamia improvement, neurofunctional deficit
scores and clinical curative effect (P > 0.05). CONCLUSION: Acupuncture can effectively improve ACI
patients' clinical symptoms and the therapeutic effect of ear-acupuncture and scalp-acupuncture was
superior to that of simple body acupuncture.
Zhen Ci Yan Jiu. 2010 Feb;35(1):56-60.
Galangin, a Flavonol
Derived from Rhizoma Alpiniae Officinarum (Gao Liang Jiang), Inhibits Acetylcholinesterase Activity in Vitro
Guo AJ, et al. Department of Biology and Center for Chinese Medicine, The Hong
Kong University of Science and Technology, Clear Water Bay Road, Hong Kong SAR, China.
Acetylcholinesterase (AChE) inhibitors are widely used for the treatment of Alzheimer's
disease (AD). Several AChE inhibitors, e.g. rivastigmine, galantamine and huperzine are originating from
plants, suggesting that herbs could potentially serve as sources for novel AChE inhibitors. Here, we
searched potential AChE inhibitors from flavonoids, a group of naturally-occurring compounds in plants or
traditional Chinese medicines (TCM). Twenty-one flavonoids, covered different subclasses, were tested for
their potential function in inhibiting AChE activity from the brain in vitro. Among all the tested
flavonoids, galangin, a flavonol isolated from Rhizoma Alpiniae Officinarum, the rhizomes of Alpiniae
officinarum (Hance.) showed an inhibitory effect on AChE activity with the highest inhibition by over 55%
and an IC(50) of 120muM and an enzyme-flavonoid inhibition constant (Ki) of 74muM. The results suggest that
flavonoids could be potential candidates for further development of new drugs against AD.
Chem Biol Interact. 2010 May 6.