Points - Recent Research
  Relative Effectiveness of Electroacupuncture and Biofeedback in Treatment of Neck and Upper Back Myofascial Pain
  Effect of Moxibustion on Intestinal Microbiome in Acute Gastric Ulcer Rats
Radix Stephaniae Tetrandrine (Fang Ji): An Emerging Role for Management of Breast Cancer

Relative Effectiveness of Electroacupuncture and Biofeedback in Treatment of Neck and Upper Back Myofascial Pain

Eslamian F1, et al.

Abstract
OBJECTIVE: To determine the differences between clinical effects of electro-acupuncture and biofeedback therapy in addition to conventional treatment in patients with cervical Myofascial Pain Syndrome (MPS).
DESIGN: Randomized clinical trial.
SETTING: Physical medicine and rehabilitation clinic of a university hospital.
PARTICIPANTS: 50 patients aged 25-55 years old of both genders with chronic neck pain diagnosed to have MPS (characterized by trigger points within taut bands) were randomly assigned into two equal groups of 25 individuals.
INTERVENTIONS: The patients in electroacupuncture group were treated with standard acupuncture concomitant electrical stimulation and those in biofeedback group received visual EMG-biofeedback therapy for muscle activity and relaxation. Both groups received the intervention 2 times a week for a total of 6 sessions. Basic exercise trainings and medicines were administered for all the patients.
OUTCOME MEASURES: Pain severity based on Visual Analogue Scale (VAS), functional status using Neck Disability Index (NDI), cervical Range of Motion (ROM) using inclinometer and Pressure Pain Threshold (PPT) using algometer were evaluated before and at 3 and 12 weeks after the treatment. Primary outcome was defined as 20% reduction in the 3-month neck pain and dysfunction compared to baseline, assessed through NDI.
RESULTS: 50 patients (39 women, 11 men) with an average age of 39.0 (5.5) years old and neck pain duration of 6.0(2.2) weeks were analyzed. All parameters, except for PPT of lower trapezius and paravertebral muscles were improved significantly in both groups, while baseline values were controlled. Achieving primary outcome was significantly more in acupuncture group compared to biofeedback group: 20 (80.0%) versus 10 (40.0%); RR = 2 with 95% CI = 1.19 to 3.36; NNT = 2.5 with 95% CI = 1.54 to 6.58. Advantages of the acupuncture over biofeedback were observed according to values obtained from NDI,VAS, extension and left lateral bending ROM and PPT on left upper trapezius after the last session of intervention until 3 months (P < 0.05).
CONCLUSION: Both electroacupuncture and biofeedback therapies were found to be effective in management of MPS when integrated with conventional treatment. However, intergroup differences showed priority of acupuncture in some parameters versus biofeedback. Thus, electro-acupuncture seems to be a better complementary modality for treatment of MPS in neck and upper back area.

Arch Phys Med Rehabil. 2020 Jan 16. pii: S0003-9993(20)30004-6. doi: 10.1016/j.apmr.2019.12.009. [Epub ahead of print]

Source: PubMed

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Effect of Moxibustion on Intestinal Microbiome in Acute Gastric Ulcer Rats

He QD1,2, et al.

Abstract
In Traditional Chinese Medicine (TCM), moxibustion had been used for thousands of years. Many clinical case reports and scientific studies had proved that moxibustion had a good effect in treating acute gastric ulcer (AGU). Some studies had shown that the relative content and species of bacteria in the intestinal would be changed when gastric mucosal injury happened. However, there was little research on the effect of intestinal microbiome with AGU rats that were treating by moxibustion. This study is aimed at analyzing the effect of fecal microbiome in rats with AGU by the 16S rDNA sequencing technology. Male SD rats were established by orally feeding once with 70% ethanol at 4 ml/kg except the control group, then treated by moxibustion in the stomach meridian group ("Liangmen," "Zusanli") and the gallbladder meridian group ("Riyue," "Yanglingquan") for 5 days. The 16S rDNA sequencing technology analysis of feces combined with histopathological methods and molecular biological detection methods was used to evaluate the therapeutic mechanism of moxibustion on AGU. AGU brought cause changes in the number and species of intestinal bacteria. Moxibustion on stomach meridian group could reduce the area of gastric mucosal injury and regulate the relative content of GAS and EGF. Moreover, moxibustion on the stomach meridian group could increase the relative content and species of beneficial bacteria in the intestine of rats with AGU. The relative abundance of intestinal probiotics was significantly upregulated in Alphaproteobacteria, Actinomycetales, and Bacillales. In addition, moxibustion might promote the repair of gastric mucosal injury by increasing the number and species of beneficial bacteria in the intestine.

Evid Based Complement Alternat Med. 2019 Dec 18;2019:6184205. doi: 10.1155/2019/6184205. eCollection 2019.

Source: PubMed

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Radix Stephaniae Tetrandrine (Fang Ji): An Emerging Role for Management of Breast Cancer

Guo Y1, et al.

Abstract
BACKGROUND: Radix Stephaniae Tetrandrine (RST), known as FangJi (Pinyin name) in Chinese, is the dried root of Stephania tetrandra S.Moore, and has been prescribed in combination with other herbs to treat cardiovascular diseases and breast cancer in traditional Chinese medicine (TCM) clinical trials.
OBJECTIVE: The aim of the review is to provide a comprehensive evaluation about application of RST in breast cancer management in TCM clinical trials, its ingredients, and its action on preventing the development of breast cancer in vitro and in vivo studies.
METHODS: Literature sources used were Pubmed, CNKI.net, Cqvip.com, and the Web of Science. For the inquiry, keywords such as Fangji, breast cancer, clinical trials, Radix Stephaniae Tetrandrine, tetrandrine, and fangchinoline were used in various combinations. About 150 research papers and reviews were consulted.
RESULTS: In TCM, RST exhibited the anti-tumor ability through its action on the bladder and lungs through dispersing phlegm and blood stasis. 10 clinical trials were identified which used RST in combination with other herbs to treat breast cancer. On average, the trials were characterized by high efficacy (>85%) and low toxicity. However, most of clinical trials are characterized as small patient samples, poor design, and different combinations of herbs in prescriptions. To date, more and more compounds have been isolated from this plant. RST exhibited anti-tumor activities by targeting reversing multidrug resistance, inhibiting cell proliferation, inducing apoptosis, preventing tumor angiogenesis, anti-oxidant, anti-inflammation, and enhancing the sensitization and attenuating the toxicity of radiotherapy.
CONCLUSION: The successful applications of RST in TCM clinical trials and preclinical experiments to beating breast cancer will provide potent lead compounds in the identification of novel anti-cancer drugs, which further contributes to the scientific exploration of functions of RST in TCM.

Curr Pharm Des. 2020 Jan 10. doi: 10.2174/1381612826666200110143706. [Epub ahead of print]

Source: PubMed

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