Evodia Fruit - Wu Zhu Yu
The pungent, bitter, and hot Wu Zhu Yu is a powerful herb in the
Chinese herbal pharmacopoeia. It is the small, reddish-brown fruit from
the Evodia tree, which is native to parts of China and Korea.
Traditionally, Wu Zhu Yu is used for its warming effects, its
pain-relieving effects, and its qi-lowering capability. It warms the
middle, disperses cold, and descends rebellious Stomach Qi.
Many formulas containing Wu Zhu Yu relieve headache, menstrual pain, and a
wide variety of digestive problems (e.g. research has found that evodia
inhibits the growth of the heliobacter pylori bacteria). Some common
formulas containing Wu Zhu Yu are: Wu Zhu Yu Tang, Si Shen Wan, and Zuo
Jin Wan. The pharmacologic properties of this fruit are: analgesic,
anthelmintic, astringent, carminative, decongestant, diuretic,
stimulant, stomachic, and uterotonic.
There is compelling research on the effects of Wu Zhu Yu’s major component: evodiamine, an alkaloidal compound. Through in vitro and in vivo
experimentation, they have found that evodiamine has anti-cancer
activities. Evodiamine has been able to inhibit proliferation, invasion,
and metastasis in a variety of tumor cell lines (including breast cancer
cells, prostate cancer cells, leukemic T-lymphocyte cells, melanoma
cells, cervical cancer cells, colon cancer cells, and lung cancer cells.
It was also able to induce apoptosis in tumor cells.
Studies have shown
that evodiamine "exhibits the strongest cytotoxicity activity against
human colon and hepatoblastoma cell lines and inhibitory activity on
human colon carcinoma cell." Interestingly, on chemoresistant breast
cancer cells, evodiamine not only sensitizes them to adriamycin (a
chemotherapy drug), but it also shows little toxicity against normal
human peripheral blood cells. This is promising news in the field of
herbology and its positive effects on the fight on cancer.
|Wu Zhu Yu
hot, slightly toxic
|| Spleen, stomach, liver, and kidney
||Warms the stomach and spleen, dispels
cold, descends rebellious chi, alleviates pain
||Abdominal pain, vomiting, acid
regurgitation, diarrhea in the morning
||Yin deficiency and excess fire